CALCINEPH-PLUS

Calcineph-Plus is a combination medication commonly used to supplement calcium and vitamin D3, often prescribed to individuals with deficiencies or increased needs for these nutrients. Here's a detailed breakdown of the drug information:

Composition:

Calcium carbonate: 1250 mg (equivalent to elemental calcium 500 mg)

Vitamin d3 (cholecalciferol): 200 iu/b>

L-methylfolate calcium :1 mg

Methylcobalamin : 1500 mcg

Pyridoxal 5 phosphate :20 mg

Calcineph-Plus is indicated for use in several specific diseases and conditions that are related to calcium and vitamin D deficiencies. Here are the primary disease indications for Calcineph-Plus:

1. Osteoporosis: o A condition characterized by weak and brittle bones, making them more susceptible to fractures. Calcineph-Plus helps improve bone mineral density and reduces fracture risk.

2. Osteopenia: o A precursor to osteoporosis where bone mineral density is lower than normal but not low enough to be classified as osteoporosis. Calcineph-Plus aids in preventing further bone density loss.

3. Hypocalcemia: o Low levels of calcium in the blood which can result from conditions such as hypoparathyroidism, chronic kidney disease, or malabsorption syndromes. Calcineph-Plus helps restore normal calcium levels.

4. Rickets and Osteomalacia: o Conditions caused by vitamin D deficiency leading to softening and weakening of bones. Rickets affects children, while osteomalacia affects adults. Calcineph-Plus provides the necessary vitamin D and calcium to strengthen bones.

5. Chronic Kidney Disease (CKD): o Patients with CKD often develop secondary hyperparathyroidism, leading to disturbances in calcium and phosphate metabolism. Calcineph-Plus helps manage these disturbances by providing necessary calcium and vitamin D.

6. Postmenopausal Osteoporosis: o Postmenopausal women are at higher risk for osteoporosis due to decreased estrogen levels. Calcineph-Plus is often prescribed to prevent and treat osteoporosis in this population.

7. Pregnancy and Lactation: o During pregnancy and lactation, there is an increased demand for calcium and vitamin D. Calcineph-Plus helps meet these increased needs to support maternal and fetal bone health.

8. Pseudohypoparathyroidism: o A genetic disorder that mimics hypoparathyroidism but is caused by resistance to the parathyroid hormone. Calcineph-Plus helps manage calcium levels in these patients.

9. Hyperparathyroidism: o In certain cases of hyperparathyroidism, where there is excessive secretion of parathyroid hormone leading to bone resorption and calcium loss, Calcineph- Plus may be used to replenish calcium.

10. Vitamin D Deficiency: o Conditions caused by inadequate levels of vitamin D, which can lead to bone disorders and muscle weakness. Calcineph-Plus provides supplemental vitamin D to address these deficiencies.

11. Osteogenesis Imperfecta: o A genetic disorder characterized by brittle bones. While the primary treatment is different, calcium and vitamin D supplementation with Calcineph-Plus can help support bone health.

Mechanism of Action:

Calcium Carbonate: Provides elemental calcium, which is crucial for bone formation and maintenance, muscle function, nerve transmission, and intracellular signalling.

Vitamin D3: Enhances the absorption of calcium from the intestine, helps in maintaining adequate serum calcium and phosphate concentrations, and supports bone mineralization.

Dosage:

Typically, one tablet daily, or as prescribed by a healthcare professional. The exact dosage may vary based on individual health needs and doctor's recommendations.

Side Effects:

Common Side Effects: Constipation, stomach upset, or gas.

Serious Side Effects: Hypercalcemia (high calcium levels) which can manifest as nausea, vomiting, stomach pain, increased thirst or urination, muscle weakness, and confusion.

Allergic Reactions: Rare but can include rash, itching/swelling, severe dizziness, and trouble breathing.

Precautions:

• Medical History: Inform the doctor about any history of kidney disease, hypercalcemia, or vitamin D toxicity.
• Drug Interactions: Calcium can affect the absorption of other medications such as bisphosphonates, certain antibiotics (like tetracyclines and quinolones), and thyroid hormones. It is advisable to space out the timing of these medications.
• Pregnancy and Breastfeeding: Generally safe, but dosage should be as per doctor's advice.

Storage:

• Store at room temperature, away from moisture and light. Keep out of reach of children.

Packaging:

1x15 (1 Strip has 15 Tablets in Alu-Alu Packaging)