CALCINEPH

Calcium Carbonate 500 mg + Vitamin D3 250 IU is a combination medication used to support bone health and treat or prevent conditions arising from calcium and vitamin D deficiencies. Here is detailed information about this combination:

Composition:

Calcium Carbonate: 500 mg (providing elemental calcium)

Vitamin D3 (Cholecalciferol): 250 IU

Mechanism of Action:

Calcium Carbonate: Provides elemental calcium, an essential mineral for the development and maintenance of healthy bones and teeth. It also plays a vital role in muscle function, nerve transmission, and intracellular signaling.

Vitamin D3: Enhances the intestinal absorption of calcium and phosphorus, which are critical for the formation and maintenance of bones. Vitamin D3 also helps in maintaining adequate serum calcium and phosphate levels, promoting normal bone mineralization.

Indications:

1. Calcium and Vitamin D Deficiency: o To treat or prevent deficiencies in calcium and vitamin D, especially in individuals with inadequate dietary intake or increased nutritional needs.

2. Osteoporosis and Osteopenia: o To help prevent and treat osteoporosis and osteopenia, particularly in postmenopausal women and elderly individuals by improving bone mineral density.

3. Hypocalcemia: o For the treatment of hypocalcemia (low levels of calcium in the blood), which can occur due to various conditions such as hypoparathyroidism.

4. Rickets and Osteomalacia: o To treat and prevent rickets (in children) and osteomalacia (in adults), both of which are caused by vitamin D deficiency leading to softening and weakening of bones.

5. Pregnancy and Lactation: o To support increased calcium needs during pregnancy and breastfeeding, ensuring adequate maternal and fetal bone health.

6. Growth and Development: o To support the increased calcium and vitamin D needs during periods of rapid growth in children and adolescents.

7. Certain Medical Conditions: o For individuals with conditions like chronic kidney disease, which may require calcium and vitamin D supplementation to manage secondary hyperparathyroidism and maintain bone health.

Dosage:

The typical dosage is one tablet daily, taken with food to enhance absorption and reduce potential gastrointestinal side effects.

The exact dosage and frequency should be determined by a healthcare provider based on individual health needs.

Side Effects:

Common Side Effects: Constipation, stomach upset, or gas.

Serious Side Effects: Hypercalcemia (symptoms include nausea, vomiting, stomach pain, increased thirst or urination, muscle weakness, and confusion), hypercalciuria (high levels of calcium in the urine), and allergic reactions (rash, itching, swelling, severe dizziness, trouble breathing).

Precautions:

Medical History: Inform the doctor about any history of kidney disease, hypercalcemia, or vitamin D toxicity.

Drug Interactions: Calcium can interfere with the absorption of other medications such as bisphosphonates, certain antibiotics (like tetracyclines and quinolones), and thyroid hormones. It's advisable to space out the timing of these medications.

Pregnancy and Breastfeeding: Generally safe, but the dosage should be as per the doctor's advice.

Contraindications:

• Hypercalcemia.
• Severe renal impairment.
• Hypervitaminosis D.
• Allergic reactions to any of the components of the medication.

Storage:

• Store at room temperature, away from moisture and light. Keep out of reach of children.

Packaging:

1x15 (1 Strip has 15 Tablets in Alu-Alu Packaging)